Description
Number of Tests Included:
Single blood test detecting unexpected antibodies against RBCs.
What is an Indirect Coombs Test?
A laboratory test that looks for antibodies circulating in the blood serum which may target foreign RBCs. These antibodies can cause transfusion reactions or affect the fetus during pregnancy.
Purpose of the Test:
Screen for antibodies before blood transfusion
Detect Rh incompatibility during pregnancy
Evaluate hemolytic disease of the newborn (HDN) risk
Identify autoimmune or drug-related hemolytic anemia
Monitor antibody levels in Rh-negative pregnant women
Who Should Get This Test?
Pregnant women, especially if Rh-negative
Individuals requiring blood transfusion
Patients with suspected antibody-mediated anemia
People with previous transfusion reactions
Individuals with autoimmune disorders affecting RBCs
Components of the Test:
Detection of unexpected RBC antibodies in serum
May include screening and identification panel
Understanding the Test Report:
Negative ICT → No harmful antibodies detected; safe for transfusion or pregnancy
Positive ICT → Antibodies present; may require:
Antibody identification
Special cross-matching for transfusion
Monitoring during pregnancy
In Pregnancy:
Positive ICT in an Rh-negative mother may mean risk of HDN—close monitoring is required.
Preparation and Procedure:
Routine blood draw
No special preparation required
How is the Test Done?
The patient’s serum is mixed with donor or test RBCs in a controlled environment. Anti-human globulin is added to detect agglutination caused by antibodies.
Best Time for Test:
Before any blood transfusion
During pregnancy (typically first visit and again at 28 weeks)
Booking and Checking Reports:
You can book the Indirect Coombs Test via SDL, arrange home blood sample collection, and view your report digitally.
